I have figured it out. I know the reason why it's always the most hardcore weebs who get into anime eventually go troon.

It all comes down to autism.

The connection with anime is clear enough to me: autists like anime mostly because all the emotions are absurdly exaggerated so even the most socially inept autist can understand it. And I think, since autists don't really identify with other people, they start to identify with all the cutesy shit to the point they feel as though that's who they actually are. Combine that with the fact that they've always felt out of place in their body, it's easy for them to convince themselves (and be groomed) into thinking that, maybe, the reason they're a socially inept loser that feels out of place is because they're actually a cute anime girl trapped in a chrischan-esque body.

So then they start trying to replicate that behavior with their knee high socks, their anime profile pic, and an almost offensive idea of who and what a woman is and how they should act. I'm not 100% sure why there's so many trannies in speed running, but i imagine the overlap of anime watchers and speed runners is quite high and the concept of playing a game over and over again so that you can do it as fast as possible sounds like a magnet for autistic people. Tbh, I feel any subculture or hobby group with lots of autists is probably filled with troons now too.